Three film students travel to Maryland to make a student film about a local urban legend, the Blair Witch. They went into the woods and never came back. One year later, the students' film and video was found in the woods. The footage was compiled and made into a movie.

George Grieves has just turned 40 and is being checked into Mt. Abaddon Hospital for a routine colonoscopy. The procedure goes wrong when charts are mixed up and the doctors make mistakes. Now, George is struggling against the nursing staff, cold hospital lawyers, an oddly distant family. To make matter worse, a formlessly sinister forces prowls the halls of the East Wing, which is currently under construction.