Dr. Drew has spent decades talking to teens and young adults about sex and relationships, so he and his daughter take on a new generation of knowledge that incorporates current concerns with TCB: trust, compassion, and boundaries. Quizzes, real questions from patients, and life-experience from Paulina help the team tackle some of the toughest stuff to talk about.

One sister is off to New York City for a scholarship competition, the other tags along with the intent to crash a video shoot. Add a truant officer, and a smuggler, and the girls soon realize that a sister can be the best friend of all.